Longevity & Energy · Research compound
MOTS-c
Mitochondrial‑derived peptide · Longevity · Energy · Metabolic
A peptide encoded in the mitochondria’s own DNA — an exercise-mimetic in the research literature.
- Form
- 10 mg — pre-reconstituted in the Cellvéra injector
- Oversight
- Licensed clinician, included
- Price
- From R3 353 / protocol
Opens a private email to our concierge · nothing is charged
Checkout begins your confidential medical intake. MOTS-c is dispensed only if a licensed clinician prescribes it after reviewing your intake — nothing is charged until your provider approves.
Pathway
A 16-amino-acid peptide with an unusual origin: it is encoded not in the cell nucleus but inside the mitochondria’s own separate DNA — one of a small family of "mitochondrial-derived peptides" discovered relatively recently.
Mechanism
It activates AMPK, the cell’s master energy sensor — the same switch that exercise and calorie restriction flip. Under metabolic stress it also moves into the nucleus and influences gene expression, which suggests mitochondria signal to the rest of the cell far more actively than was once assumed.
Studied for
- Insulin sensitivity and metabolic health
- Obesity and age-related metabolic decline
- Exercise capacity — sometimes described as an exercise mimetic
Areas of research interest — not promised outcomes.
Where the evidence stands
Compelling mouse and cell research from academic groups, and an interesting observation that a MOTS-c variant is associated with longevity in some Japanese populations. Human interventional data is essentially absent.
Typical protocol
Dosing is individualised and set by your supervising clinician at intake. Published human dosing for this compound is not established; conservative titration and monitoring are part of every protocol.
Contraindications & cautions
An early-stage research compound with no human approval. No established dosing or safety profile. Pregnancy or breastfeeding.
Prescribed only after evaluation by your supervising provider, based on your history and bloodwork.